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KARUSSIS Dimitrios

Tel.: +972 2 6777111

Fax: +972 2 6437782

e-mail: Karus@cc.huji.ac.il

Address

Hadassah University Hospital

Department of Neurology

Hadassah Em-Kerem

Jerusalem - Israel

Research themes

Immunomodulation of EAE; immune mechanisms in the acute and chronic (actively and passively induced) model of EAE; new immunotherapies; T-cell vaccination in EAE and MS patients; cDNA vaccination in EAE; adhesion molecules and CD44 in EAE; chemokines and chemokine receptors in MS patients; FACS analysis of lymphocytes from MS patients during relapses and remissions; PCR analysis of cytokines and chemokines in EAE; Clinical trials in MS; Copaxone; Linomide; Oral interferons in EAE; Bone marrow transplantation in EAE, MS and autoimmune diseases; Neuronal stem cell transplantation in EAE and other experimental neurological diseases; APOE subtypes in animal models of Alzheimer’s disease and EAE; Inflammatory mechanisms in Alzheimer’s diease

Key words

  

Methods

  

Composition of the research group

Oded Abramsky

MD, PhD, Neurologist, Neuroimmunologist

  

Haim Ovadia

PhD, Neuroimmunologist

  

Talma Brenner

PhD, Neuroimmunologist

  

Dimitrios Karussis

MD, PhD, Neurologist, Neuroimmunologist

  

Tamir Ben-Hur

MD, PhD, Neurologist, Neuroimmunologist

  

Rachel Mizrahi-Koll

Technician

  

Camill Sicsic

Technician

  

Fanny Bitchem

Technician

  

Recent publications

  1. Karussis, D., Meiner, Z., Lehmann, D., Gomori, M., Schwarz, A., Linde, A., Gjorstrup, P., Abramsky, O. Treatment of secondary progressive multiple sclerosis with the immunomodulator Linomide: A pilot double blind placebo controlled study with monthly MRI evaluation. Neurology 47:341-346 (1996).

  2. O. Abramsky, D. Lehmann, and D. Karussis. Treatment of multiple sclerosis with linomide. Multiple sclerosis 2: 206-210 (1996).

  3. Lehmann, D., Karussis, D., Fluresco, D., Mizrachi-Koll, R., Ovadia, H., Shezen, E., Kalland, T., Abramsky, O. Immunomodulation of autoimmunity by linomide (quinoline-3-carboxamide): inhibition of antigen presentation through downregulation of macrophage activity. J. Neuroimmunol. 74: 102-110 (1997).

  4. D. Lehmann, D. Karussis, R. Mizrachi-Koll, A. Linde, O. Abramsky. Inhibition of the pregression of multiple sclerosis by linomide is associated with upregulation of CD4+/CD45Ra+ cells and downregulation of CD4+/CD45Ro+ cells. Clin. Immunol. Immunopathol. 85: 202-209 (1997)

  5. Y. Wenefeld, D. Karussis, O. Abramsky, D. Lehmann, I. Arbel, H. Ovadia. Linomide activates the adrenocortical axis in the rat: Inhibition of EAE by linomide is not related to the increase of corticosterone. J. Neuroimmunol. 79:49-53. (1997).

  6. D. Karussis, O. Abramsky. Review: Immunomodulating therapeutic approaches in multiple sclerosis. J. Neurol. Sci. 153:(2):239-251 (1998).

  7. D. Karussis, A. Ashkenazi, R. Leker, O. Abramsky. A subgroup of MS patients and anticardiolipin Abs and unusual clinical manifestations; Do they represent a new nosological entity ? Ann. Neurol. 1998: 44:629-634.

  8. T. Karpathi, D. Karussis, D. Lehmann, R. Mizrachi-Koll, I. Arbel, O. Abramsky, H. Ovadia. Immunomodulation of experimental autoimmune neuritis with linomide. Immunol. Letters (1998). 63:141-145.

  9. OJ. Kwon, A. Karni, S. Israel, C. Brautbar, A. Amar, Z. Meiner, O. Abramsky, and D.Karussis. HLA Class II susceptibility to multiple sclerosis among Ashkenazi and non- Ashkenazi Jews. Arch. Neurol. (1999). 56:555-560.

  10. I.Arbel, D. Karussis, D, Lehmann, R. Mizrach-Koll, E. Shetzen, H. Ovadia, O. Abramsky. Effects of linomide on the thymus: Induction of apoptosis of the early CD4/CD8 double positive cortical thymocytes. Clin Immunol. Immunopathol. 1998 (in press).

  11. D. Karussis, D. Lehmann, I. Arbel, R. Mizrachi-Koll, O. Abramsky, H. Ovadia. Linomide downregulates autoimmunity through induction of TH-2 cytokine production by lymphocytes. Immunol. Lett. (1999). 67:203-208.

  12. D. Karussis, O. Abramsky. Is the routine use of intravenous gamma globulin treatment in neurological disorders justified ? The cons. Arch. Neurol. (1999) (in press).

  13. D. Karussis, U. Vourka-Karussis, R. Mizrachi-Koll, O. Abramsky. Acute/relapsing experimental autoimmune encephalomyelitis: Induction of long-term, antigen specific tolerance by syngeneic bone marrow transplantation. Multiple Sclerosis- 1999. 5:17-21.