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LASSMANN Hans

Tel.: +43-1-4277-62811 (-62801/-62810)

Fax: +43-1-4277-9628

e-mail: hans.lassmann@univie.ac.at

 

Address

Brain Research Institute

Division of Neuroimmunology

University of Vienna

Spitalgasse 4, A-1090 Vienna, Austria

Research themes

Immune surveillance of the central nervous system; pathogenesis of inflammatory demyelinating diseases including multiple sclerosis and the respective experimental models of autoimmune encephalomyelitis;

Immunopathology of inflammatory brain diseases

Key words

Cell trafficking in the central nervous system, autoreactive T-cell and autoantibodies, brain inflammation, demyelination, remyelination, axonal injury, multiple sclerosis, meningitis, encephalomyelitis

Methods

Neuropathology, immunocytochemistry, in situ hybridization,

T-cell and B-cell immunology, molecular biology

Composition of the research group

Jan BAUER

PhD, Immunopathology

Brain Research Institute

Johannes BERGER

PhD, Molecular Biology

Brain Research Institute

Sonja FORSS-PETTER

PhD, Molecular Biology

Brain Research Institute

Hans LASSMANN

MD, Neuroimmunology

Brain Research Institute

Beatrix SCHWERER

PhD, Neuroimmunology

Brain Research Institute

Recent publications

  1. Kerschensteiner M, Gallmeier E, Behrens L, Klinkert WEF, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999) Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation ? J Exp Med 189:865-870

  2. Weerth S, Berger T, Lassmann H, Linington C (1999) Encephalitogenic and neuritogenic T-cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat. J Neuroimmunol 95:157-164

  3. Bauer J, Stadelmann C, Bancher C, Jellinger K, Lassmann H (1999) Apoptosis of T-lymphocytes in acute disseminated encephalomyelitis. Acta Neuropathol 97:543-546

  4. Kassiotis G, Bauer J, Akassoglou K, Lassmann H, Kollias G, Probert L (1999) A tumor necrosis factor-induced model of human primary demyelinating disease develops in immunodeficient backgrounds. Eur J Immunol 29:912-917

  5. Bradl M, Bauer J, Inomata T, Zielasek J, Nave KA, Toyka K, Lassmann H, Wekerle H (1999) Transgenic Lewis rats overexpressing the proteolipid protein gene : myelin degeneration and its effects on T-cell mediated experimental autoimmune encephalomyelitis. Acta Neuropathol 97 :595-606

  6. Schmidt S, Hertfelder HJ, von Spiegel T, Hering R, Harzheim M, Lassmann H, Deckert-Schlüter M, Schlegel U (1999) Lethal capillary leak syndrome following a single administration of interferon beta-1b. Neurology 53 :220-222

  7. Kuhlmann T, Lucchinetti CF, Zettl UK, Bitsch A, Lassmann H, Brück W 1999 Bcl-2 expressing oligodendrocytes in multiple sclerosis. Glia 28:34-39

  8. Bittner R, Anderson LVB, Burkhardt E, Bashir R, Vafiadaki E, Raffelsberger T, Maerk I, Höger H, Jung M, Karbasiyan M, Storch M, Lassmann H, Moss JA, Davison K, Harrison R, Bushby KMD, Reis A (1999) Dysferlin gene-deletion in the SJL mouse (dysf/sjl) defines a naturally occuring model for limb girdle muscular dystrophy 2B (LGMD 2B) and Miyoshi Myopathy. Nature Genetics 23:141-142

  9. Kornek B, Lassmann H (1999) Axonal pathology in multiple sclerosis: a historical note. Brain Pathol 9:651-656

  10. Stefferl A, Brehm U, Storch M, Lambracht-Washington D, Bourquin C, Wonigeit K, Lassmann H, Linington C (1999) Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the resistant Brown Norway rat: Disease susceptibility is determined by MHC and MHC-linked effects on the B-cell response. J Immunol 163:40-49

  11. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H 1999 A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 117 cases. Brain, 122:2279-2295

  12. Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Brück W, Jellinger K, Lassmann H (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer’s disease. Amer J Pathol 155:1459-1466

  13. Dewey RA, Morrissey G, Coswill CM, Stone D, Bolognami F, Dodd NJF, Southgate TD, Klatzmann D, Lassmann H, Castro MG, Löwenstein PR (1999) Chronic brain inflammation and persistent HSV1-TK expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials. Nature Med 5:1256-1263

  14. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol 47:707-717

  15. Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C,Schmidbauer M, Lassmann H (2000) Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis. A comparative quantitative study of axonal injury in active, inactive and remyelinated lesions. Amer J Pathol 157:267-276

  16. Stadelmann C, Lassmann H (2000) Detection of apoptosis in tissue sections. Cell Tissue Res 301:19-31

  17. Kornek B, Storch MK, Djamshidian L, Weissert R, Wallstroem E, Stefferl A, Zimprich F, Olsson T, Linington C, Schmidbauer M, Lassmann H (2000) Expression of c calcium channel subunit in dystrophic axons of multiple sclerosis and experimental autoimmune encephalomyelitis. Brain submitted