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Miller Ariel

Tel.: +972 4 8250 851

Fax: +972 4 8250 909

e-mail: millera@tx.technion.ac.il

 

Address

Ariel Miller, MD, PhD
Division of Neuroimmunology & Multiple Sclerosis Center
Carmel Medical Center
7 Michal Street, Haifa 34362, Israel

Research themes

Our studies in MS also focus on the "invasive profile " of the activated immune cells in the periphery, specifically at their activation markers, cytokines, matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) secretion pattern. An additional part of our research of the mechanisms of brain injury comprises the examination of the inflammatory cascade that follows cerebral ischemia and hypoxic-tolerance, both in experimental models as well as in stroke patients

Key words

Neuroimmunology, Autoimmunity, Multiple Sclerosis, EAE, Stroke, Inflammatory mediators (cytokines, chemokines), T cells, matrix metalloproteinases (MMPs), TIMPs, migration, demyelination, Immunomodulation, repair.

Methods

Cell cultures (bulk, primary, organotypic, lines), cellular immunology (T cell proliferation and cytotoxic assays, FACS analysis), protein analyses (PAGE, IEF, Western blotting), molecular biology (Southern and Northern blotting, recombinant DNA techniques), cytokine detection systems (ELISA, intracellular staining, RT-PCR, ISH), chemokine and chemokine receptor detection systems (RPA, ISH), animal models (EAE, focal cerebral ischemias), zymography.

Composition of the research group

Saraha Shapiro

PhD Immunology

Carmel Medical Center

Ronit Weinberger

PhD Biochemistry

Carmel Medical Center

Hanna Rawashdeh

MD, Neurologist

Carmel Medical Center

Michal Avram

PhD Student

Carmel Medical Center

Yaara Ben Basat

PhD Student

Carmel Medical Center

Yanina Galgoiz

PhD Student

Carmel Medical Center

Ariel Miller

MD, PhD, Neuro-Immunologist

Carmel Medical Center

Recent publications

  1. Miller, A., Lider, O. and Weiner L.H. Antigen driven bystander suppression after oral administration of antigens. J. Exp. Med. 174, 791-798, 1991
  2. Miller A., O. Lider, A.B. Roberts, B.M. Sporn, and H.L. Weiner. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGF-b after antigen-specific triggering. Proc. Natl. Acad. Sci. USA , 89: 421-425, 1992.
  3. Miller A., N. Lanir, S. Shapiro, M. Revel, S. Honigman, A. Kinarty and N. Lahat. Immunoregulatory effects of interferon-b and interacting cytokines on human vascular endothelial cells. Implications for multiple sclerosis. J. Neuroimmunol. 64: 151-161, 1996.
  4. Barone FC, B. Arvin, R.F. White, A. Miller, C.L. Webb, R.N. Willette, P.G. Lysk and G.Z. Feuerstein. Tumor necrosis factor-a : A mediator of focal ischemic brain injury. Stroke. 28: 1233-1244, 1997.
  5. Sorkine P., A. Setton, P. Halpern, A. Miller, V. Rudick, S. Marmor, J.M. Klausner, and G. Goldman. Solouble TNF receptors reduce bowel ischemia-induced lung permiability and neutrophils sequestration. Critical Care Med. 23: 1377-1381, 1995.
  6. Zhang, J., Hohlfeld, R., Hafler, D. and Miller, A.,Eds. Immunotherapy in NeuroImmunological Diseases. Martin Dunitz Publishers, London. 1998.
  7. Weiner H.L. & A. Miller. Oral Tolerance: Basic mechanisms and implications to immune-mediated neurological diseases. In: Immunotherapy in NeuroImmunology. J. Zhang, R. Hohlfeld, D. Hafler & A. Miller (Eds.). Martin Dunitz Publishers. London. 1998. p. 233-143.
  8. Miller, A., Shapiro, S., Kinarty, A., Gershtein, R., Rawashdeh, H., Honigman, S. and Lahat, N. Treatment of Multiple Sclerosis with Copolymer-1: implicating mechanisms of Th1 to Th2/Th3 immune-deviation. J. Neuroimmunol. 92, 113-121. 1998.
  9. Lahat N., S. Shapiro, M. Inspector, R. Reich, R. Gershtein & A. Miller. Matrix Metaloproteinases (MMPs in astroglial cells. In: Progress in Alzheimer's and Parkinson's Diseases. A. Fisher, I. Hanin. and M. Yoshida (Eds.). Plenum Press. 1998. p. 149-157.
  10. Miller A., S. Shapiro & N. Lahat. Immunomodulation in multiple sclerosis and cytokine responses. In: Frontiers in Multiple Sclerosis-II. Kesselring, Siva and Thompson (Eds.) Martin Dunitz Publishers. London, 1999. p . 127-138.