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MONTALBAN Xavier |
Tel.: +34 93 274 6202
Fax: +34 93 274 6084
e-mail: xmontal@hg.vhebron.es |
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Address |
Unitat de Neuroimmunologia Clínica
Hospital General Universitari Vall d'Hebron
Escola Universitària d’Infermeria - Ps. Vall d'Hebron, 119-129
E-08035 Barcelona , Spain |
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Research themes |
Primary progressive MS, immunological features in MS relapses, neurotrophic factors in EAE/MS, role of cytokines and oxidative stress in the pathogenesis of MS, genetics in MS, searching for new therapies for MS in the EAE model. |
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Key words |
T cells, B cells, neurotrophic factors (BDNF, GDNF, IL-6), inflammatory mediators (cytokines, chemokines), EAE, MS, oxidative stress, immunotherapies, IFN-beta, clinical relapse. |
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Methods |
Cell cultures (bulk, primary, organotypic lines), cellular immunology (T-cell proliferation, FACS analysis), protein analyses (PAGE, UIEF, Western blot), molecular biology (Southern and Northern blot), cytokine detection systems (ELISA, intracellular staining, RT-PCR), chemokine and chemokine receptor detection systems (RPA), immunocytochemistry, animal models (EAE). |
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Composition of the research group |
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Xavier Montalban |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Mar Tintoré |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Jordi Rio |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Eva Mª Martínez-Cáceres |
MD, PhD Immunologist |
Unitat de Neuroimmunologia Clínica |
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Pablo Villoslada |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Manuel Comabella |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Carlos Nos |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Luis Brieva |
MD, Neurologist |
Unitat de Neuroimmunologia Clínica |
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Irene Sáez-torres |
BS, Pharmacist |
Unitat de Neuroimmunologia Clínica |
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Miquel Barrau |
BS, Biologist |
Unitat de Neuroimmunologia Clínica |
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Isabel Durán |
BS, Chemist |
Unitat de Neuroimmunologia Clínica |
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Carmen Espejo |
BS, Biologist |
Unitat de Neuroimmunologia Clínica |
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Manuel Oliva |
BS, Biologist |
Unitat de Neuroimmunologia Clínica |
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Narcís Barberà |
BS, Biologist |
Unitat de Neuroimmunologia Clínica |
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Recent publications
- Sáez-Torres I, Diaz-Villoslada P, Martinez-Caceres, E, Ferrer I, Montalban X. Gangliosides do not elicit experimental autoimmune encephalomyelitis in Lewis rats and SJL mice. J Neuroimmunol 1998; 84: 24-29.
- Río J, Nos C, Marzo ME, Tintoré M, Montalban X. Low-dose steroids reduce flu-like symptoms at the initiation of IFNb
-1b in relapsing-remitting MS. Neurology 1998; 50: 1910-1912.
- Martínez-Cáceres EM, Río J, Barrau M, Durán I, Borrás C, Tintoré M, Montalban X. Amelioration of flu-like symptoms at the onset of Ifn-B 1b therapy in MS by low oral steroids use in related to a decrease in IL-6 induction. Ann Neurol 1998; 44: 682-685.
- Diaz-Villoslada P, Oksenberg J.R. Chronic inflammatory diseases of the nervous system. Curr Opin Neurol 1998; 11: 235-240.
- European Study Group on Interferon b
-1b in Secondary Progressive MS (investigators: J. Montalban, J. Río, M. Tintoré, C. Jacas, E. Marzo et al.). Placebo-controlled multicentre randomised trial of interferon b
-1b in treatment of secondary progressive mulitple sclerosis. Lancet 1998; 352: 1491-1497.
- Stevenson VL, Miller DH, Rovaris M, Barkhof F, Brochet B, de Pijer S, de Sa J, Dousset V, Filippi M, Montalban X, Polman CH, Rovira A, Thompson Aj. Primary and transitional progressive mulitple sclerosis. A clinical and MRI cross-sectional study. Neurology 1999; 52: 839-845.
- Borràs C, Río J, Porcel J, Barrios M, Tintoré M, Montalban X. Emotional state of patients with relapsing-remitting MS treated with interferon Beta-1b. Neurology 1999; 52: 1636-1639.
- Rovira A, Alonso J, Cucurella MG, Nos C, Tintoré M, Pedraza S, Río J, Montalban X. The evolution of multiple sclerosis lesions on serial magnetization transfer and contrast-enhanced MR imaging.Am J Neuroradiol (In press).
- Durán I, Martínez-Cáceres E, Río J, Barberà N, Marzo ME, Montalban X. Immunological profile of patients with primary progressive multiple sclerosis. Expression of adhesion molecules. Brain (In press).
- Tintoré M, Rovira A, Martínez M. J., Río J, Díaz-Villoslada P, Brieva L, Borrás C, Grive E, Capellades J, Montalban X. Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to CDMS. A J Neuroradiol (In press).
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