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BAUMANN Nicole
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Tel.: +33-1-4216-2155
Fax: +33-1-4584-8008
e-mail: baumann@ccr.jussieu.fr
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Address
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Laboratoire de Neurochimie INSERM Unit 495
Salpetriere Hospital
47 Bd de l'Hopital 75651 Paris cedex 13, France
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Research themes
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Autoimmunity in CNS and PNS, Human peripheral neuropathies. Glycolipid antigens
and cellular markers. Glycolipids in degenerative diseases and myelin disorders.
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Key words
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Glycolipid antigens, gangliosides, cellular markers, dysimmune neuropathies,
autoimmunity, degenerative diseases, multiple sclerosis, mass spectrometry.
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Methods
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Immunodetection of glycolipid antigens by ELISA and after thin-layer
chromatography, lysosomal enzymes, cell cultures, metabolic studies, glycolipid biochemical
characterization, purification of lipids, mass spectrometry of glycolipids and ceramides, molecular biology.
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Composition of the research group
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Nicole BAUMANN
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MD, PhD, neurologist, biochemist
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INSERM Unit 495 Salpetriere Hospital, Paris
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Benoit COLSCH
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Biochemist- Assistant ingenieur
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INSERM U 495 Salpetriere Hospital, Paris
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Mireille LEFEVRE
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Biochemist- Assistant ingenieur
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INSERM U 495 Salpetriere Hospital, Paris
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Jean-Claude TURPIN
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Neurologist
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INSERM Unit 495 Salpetriere Hospital, Paris
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Jacques PORTOUKALIAN
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Biochemist
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INSERM U 346 Edouard Herriot Hospital, Lyon
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Recent publications
- BAUMANN N , TURPIN JC Adult onset leukodystrophies. J Neurol 2000, 247: 251-259.
- BAUMANN N. Specificity of antiglycolipid antibodies. Clin. Rev. Allergy and Immunol. 2000, 19: 31-40.
- LEGER JM, CHASSANDE B, MUSSET L, MEININGER V, BOUCHE B, BAUMANN N. Intravenous immunoglobulin
therapy in multifocal motor neuropathy. A double-blind placebo-controlled study. Brain 2001, 124: 145-153.
- BAUMANN N, PHAM-DINH D. Biology of oligodendrocytes and myelin in the mammalian central nervous system.
Physiological Reviews 2001, 81: 871-927.
- BAUMANN N, TURPIN JC, LEFEVRE M, COLSCH B. Motor and psycho-cognitive clinical types in adult
metachromatic leukodystrophy : genotype/phenotype relationships ? J Physiol (Paris) 2002, 96: 301-306.
- BAUMANN N, AUBRY J. Lipides du nerf peripherique. Encycl.Med.Chir.Elsevier Paris. Neurologie (2003) 17-030 F10 pp 1-9
- BAUMANN Nicole, THURIN JM Stress, Pathologies et Immunite. Flammarion Medecine Science Pub. 2003, 287 pages
- DELARASSE C, COLOMAR A, RODRIGUEZ D, BAUMANN N, AMEDEE T, PHAM-DINH D. Myelin genes and proteins.
(RA Lazzarini, JW Griffin, H Lassman, KA Nave, RH Miller, BD Trapp) in Myelin Biology and disorders
Elsevier Academic Press. 2004, pp
- VARKONYI J, ROSENBAUM H, BAUMANN N, MACKENZIE JJ, SIMON Z, AHARON J,
WALKER JM, TAYEBI N, SIDRANSKY E. Gaucher disease associated with Parkinsonism.
Am J Med Genet. 2003, 116A: 348-51.
- COLSCH B, AFONSO C, POPA I, PORTOUKALIAN J, FOURNIER F, TABET JC, BAUMANN N. Characterization of the
ceramide moieties of sphingoglycolipids from mouse brain ESI-MS/MS : identification of ceramides containing
sphingadienine. J Lipid Res 2004, 45 : 281-286.
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