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HARTUNG Hans-Peter

Tel.: +49 211 81 17880

Fax: +49 211 81 18469

e-mail: Hans-Peter.Hartung@uni-duesseldorf.de

 

Address

Heinrich-Heine-Universität

Neurologische Klinik

Moorenstrasse 5

D-40225 Duesseldorf

Germany

Research themes

Pathogenesis of immune-mediated demyelinating diseases of the central and peripheral nervous system

Key words

Inflammatory mediators such as adhesion molecules, cytokines, chemokines, matrix metalloproteinases, T lymphoctes, B cells, demyelination, remyelination, trophic factors, EAE, EAN

Methods

Cell cultures (bulk, primary, organotypic, lines), cellular immunology (proliferation and cytotoxic assays, FACS analysis - surface and intracellular staining), protein analysis (PAGE, IEF, Western blotting, ELISA), molecular biology (competitive RT-PCR, Southern and Northern blotting, recombinant DNA techniques, Rnase Protection Assay, Micro Array, ISH), immunohistochemistry, laser capture microdissection, electronmicroscopy, animal models (EAE, EAN, stroke)

Composition of the research group

Bernhard HEMMER

MD Neurologist

Sebastian JANDER

MD Neurologist

Bernd C. KIESEIER

MD Neurologist

Hubertus KÖLLER

MD Neurologist

Oliver NEUHAUS

MD Neurologist

Fabian BERNAL

PhD Biologist

Thomas DEHMEL

PhD Biologist

Wei HU

MD Neurologist

Martin KURZ

MD Neurologist

Philipp ZICKLER

MD Neurologist

Michael SCHROETER

MD Neurologist

Fredericke VOGEL

MD Neurologist

Berit ROSCHE

MD Neurologist

Recent publications

  1. DE JONGHE P., M. AUER-GRUMBACH, J. IROBI, K. WAGNER, B. PLECKO, M. KENNERSON, D. ZHU, E. DE VRIENDT, V. VAN GERWEN, G. NICHOLSON, H.-P. HARTUNG AND V. TIMMERMAN.(2002) Autosomal dominant juvenile amyotrophic lateral sclerosis and distal hereditary motor neuronopathy with pyramidal tract signs: synonyms for the same disorder? Brain 125: 1320-5

  2. DAWKINS J.L., S. BRAHMBHATT, M. AUER-GRUMBACH, K. WAGNER, H.-P. HARTUNG, K. VERHOEVEN, V. TIMMERMAN, P. DE JONGHE, M. KENNERSON, E. LEGUERN AND G.A. NICHOLSON.(2002) Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy. Neuromuscular Disorders 12: 656-8

  3. BAUMHACKL U., G. EIBL, U. GANZINGER, H.-P. HARTUNG, B. MAMOLI, K.P. PFEIFFER, F. FAZEKAS AND K. VASS.(2002) Prevalence of multiple sclerosis in Austria. Results of a nationwide survey. Neuroepidemiology 21: 226-34

  4. GHALIE R.G., G. EDAN, M. LAURENT, E. MAUCH, S. EISENMAN, H.-P. HARTUNG, R.E. GONSETTE, M.D. BUTINE AND D.E. GOODKIN.(2002a) Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS. Neurology 59: 909-13

  5. GHALIE R.G., E. MAUCH, G. EDAN, H.-P. HARTUNG, R.E. GONSETTE, S. EISENMANN, E. LE PAGE, M.D. BUTINE AND D.E. DE GOODKIN.(2002b) A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis. Multiple Sclerosis 8: 441-5

  6. NEUHAUS O., S. STRASSER-FUCHS, F. FAZEKAS, B.C. KIESEIER, G. NIEDERWIESER, H.-P. HARTUNG AND J.J. ARCHELOS.(2002) Statins as immunomodulators: comparison with interferon-beta 1b in MS. Neurology 59: 990-7

  7. CLANET M., E.W. RADUE, L. KAPPOS, H.-P. HARTUNG, R. HOHLFELD, M. SANDBERG-WOLLHEIM, M.F. KOOIJMANS-COUTINHO, E.C. TSAO AND A.W. SANDROCK.(2002) A randomized, double-blind, dose-comparison study of weekly interferon beta-1a in relapsing MS. Neurology 59: 1507-17

  8. SEIFERT T., B.C. KIESEIER, S. ROPELE, S. STRASSER-FUCHS, F. QUEHENBERGER, F. FAZEKAS AND H.-P. HARTUNG.(2002) TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis. Multiple Sclerosis 8: 447-51

  9. HARTUNG H.-P., R. GONSETTE, N. KONIG, H. KWIECINSKI, A. GUSEO, S.P. MORRISSEY, H. KRAPF AND T. ZWINGERS.(2002a) Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial. Lancet 360: 2018-25

  10. ENZINGER C., S. ROPELE, S. STRASSER-FUCHS, P. KAPELLER, H. SCHMIDT, B. POLTRUM, R. SCHMIDT, H.-P. HARTUNG AND F. FAZEKAS.(2003) Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele. Archives Neurology 60: 65-70

  11. VERHOEVEN K., P. DE JONGHE, K. COEN, N. VERPOORTEN, M. AUER-GRUMBACH, J.M. KWON, D. FITZPATRICK, E. SCHMEDDING, E. DE VRIENDT, A. JACOBS, V. VAN GERWEN, K. WAGNER, H.-P. HARTUNG AND V. TIMMERMAN.(2003) Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. American Journal Human Genetics 72: 722-7

  12. PETEREIT H.F., R. PUKROP, F. FAZEKAS, S.U. BAMBORSCHKE, S. ROPELE, H.W. KOLMEL, S. MERKELBACH, G. JAPP, P.J. JONGEN, H.-P. HARTUNG AND O.R. HOMMES.(2003) Low interleukin-10 production is associated with higher disability and MRI lesion load in secondary progressive multiple sclerosis. Journal Neurological Sciences 206: 209-14

  13. KASTENBAUER S., U. KOEDEL, M. WICK, B.C. KIESEIER, H.-P. HARTUNG AND H.W. PFISTER.(2003) CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system. Journal of Neuroimmunology 137: 210-7

  14. KIESEIER B.C., H. PISCHEL, E. NEUEN-JACOB, W.W. TOURTELLOTTE AND H.-P. HARTUNG.(2003) ADAM-10 and ADAM-17 in the inflamed human CNS. Glia 42: 398-405

  15. FREEDMAN M., J. KING, J. OGER, M. SHARIEF AND H.-P. HARTUNG.(2003) Interferons in relapsing remitting multiple sclerosis. Lancet 361: 1822-3; author reply 1823-4

  16. BARKHOF F., M. ROCCA, G. FRANCIS, J.H. VAN WAESBERGHE, B.M. UITDEHAAG, O.R. HOMMES, H.-P. HARTUNG, L. DURELLI, G. EDAN, O. FERNANDEZ, P. SEELDRAYERS, P. SORENSEN, S. MARGRIE, M. ROVARIS, G. COMI AND M. FILIPPI.(2003) Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon beta1a. Annals of Neurology 53: 718-24

  17. PAUL R., U. KOEDEL, F. WINKLER, B.C. KIESEIER, A. FONTANA, M. KOPF, H.-P. HARTUNG AND H.W. PFISTER.(2003) Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain 126: 1873-82

  18. WIENDL H., O. NEUHAUS, M. MEHLING, S. WINTTERLE, B. SCHREINER, M. MITSDOERFFER, W. WIENHOLD, R. WEISSERT, J. WESSELS, H.-P. HARTUNG, M. WELLER, E. TOLOSA AND A. MELMS.(2003) The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. Journal of Neuroimmunology 140: 177-87

  19. HOMANN C.N., F. QUEHENBERGER, K. PETROVIC, H.-P. HARTUNG, E. RUZICKA, B. HOMANN, K. SUPPAN, K. WENZEL, G. IVANIC AND E. OTT.(2003) Influence of age, gender, education and dexterity on upper limb motor performance in Parkinsonian patients and healthy controls. Journal of Neural Transmission 110: 885-97

  20. SCHROETER M., G. STOLL, R. WEISSERT, H.-P. HARTUNG, H. LASSMANN, S. JANDER (2003) CD8(+) phagocyte recuritment in rat experimental autoimmune encephalomyelitis: association with inflammatory tissue destruction. American Journal of Pathology 163: 1517-24

  21. KAPPOS L., POLMAN C., THOMPSON AJ, DUDA P., CLANET M., COMI G., H.-P. HARTUNG, MONTALBAN X. (2003) Towards a European network for multiple sclerosis trials (ENMST). Multiple Sclerosis 9: 627-9

  22. KOLLER H., KORNISCHKA J., NEUEN-JACOB E., SALEH A., VON GIESEN HJ, SCHMIEDEL J., REICHMANN H., H.-P. HARTUNG (2003) Persistent organic personality change as rare psychiatric manifestation of MELAS syndrome. Journal of Neurology 250: 1501-2.

  23. LEHMANN HC, H.-P. HARTUNG, KIESEIER BC (2003) The prefaces of Charcot: leitmotifs of an international career. Neurology 28; 61: 1163.

  24. HU W., MATHEY E., H.-P. HARTUNG (2003) Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve. Neurology 23; 61: 1774-9.

  25. JUNG S., GAUPP S., KORN TL, KOLLNER GL, H.-P. HARTUNG, TOYKA K.V. (2004) Biphasic form of experimental autoimmune neuritis in dark agouti rats and its oral therapy by antigen-specific tolerization. Journal of Neuroscience Research 75 (4): 524-35.

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