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HINTZEN Rogier
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Tel.: +31 10 4633780 (semaphone 35713)
Fax: +31 4635927
e-mail:
rhintzen@xs4all.nl
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Address
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Dept of Neurology
Academic Hospital Rotterdam
Postbox 2040
3000 CA Rotterdam
The Netherlands
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Research themes
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Role of infections and co-stimulatory molecules
in neuroimmunological disease (focus on MS and GBS). Markers of
disease activity. Genetic Epidemiology of MS. Paraneoplastic diseases.
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Key words
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Inflammatory markers and mediators, T cells,
dendritic cells, viruses, MS, GBS, EAE, TNF-receptor family, Toll
like receptors, genetic epidemiology
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Methods
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Cellular immunology (T cell proliferation and cytotoxic assays, FACS analysis), protein analyses (PAGE, IEF, Western blotting),
molecular biology (real time PCR, array), proteomics, growth factor quantification, intracellular staining, immunocytochemistry, animal models (EAE),
proteomics.
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Composition of the research group
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JD Laman
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PhD, Immunologist
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MS Centre ErasMS
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L Boven
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PhD, Immunologist
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MS Centre ErasMS
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B ´t Hart
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PhD, Immunologist
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MS Centre ErasMS
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S Amor
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PhD, Immunologist
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MS Centre ErasMS
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RQ Hintzen
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MD PhD, Neurologist/Immunologist
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MS Centre ErasMS
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B Jacobs
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MD PhD, Neurologist
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GBS group
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PA van Doorn
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MD PhD, Neurologist
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GBS group
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P Sillevis Smitt
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MD PhD, Neurologist
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Paraneoplastic diseases
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T Luider
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PhD, Biochemist
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Erasmus proteomics facility
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Recent publications
- BULJEVAC D, VERKOOYEN RP, JACOBS BC, HOP W, VAN DER ZWAAN LA, VAN DOORN PA, HINTZEN RQ. Serologically defined Chlamydia Pneumoniae
infections are associated with the risk for exacerbation in multiple sclerosis patients. Annals of Neurology, 2003, 54(6): 828-831
- BULJEVAC D, FLACH HZ, HOP WCJ, HIJDRA D, LAMAN JD, SAVELKOUL HFJ, VAN DER MECHÉ FGA, VAN DOORN PA, HINTZEN RQ.
Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain 2002, 125: 952-960.
- BULJEVAC D., WCJ HOP, W REEDEKER, ACJW JANSSENS, FGA VAN DER MECHÉ, PA VAN DOORN, RQ HINTZEN. Stressful life events
and exacerbations of multiple sclerosis. British Medical Journal 2003;327:646-50.
- SILLEVIS SMITT P, KINOSHITA A, DELEEUW B, MOLL W, JAARSMA D, HENZEN-LOGMANS S, VECHT C, DE ZEEUW C, SEKIYAMA N,
NAKANISHI S, SHIGEMOTO R. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor.
New Engl J Med 2000;342:21-28.
- DE VOS AF, VAN MEURS M, BROK HP, BOVEN LA, HINTZEN RQ, VAN DER VALK P, RAVID R, RENSING S, BOON L, 'T HART BA, LAMAN JD.
Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J.Immunol. 2002 15;169(10):5415-23.
- VISSER L DE VOS AF, HAMANN J, MELIEF MJ, VAN MEURS M, VAN LIER RA, LAMAN JD, HINTZEN RQ. Expression of the EGF-TM7
receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. J Neuroimmunol. 2002 132(1-2)156-63.
- HINTZEN RQ Stem cell transplantation in Multiple Sclerosis: Multiple choices and multiple challenges.
Multiple Sclerosis 2002; 8: 155-160
- L. BOON, H.P.M. BROK, J. BAUER, A. ORTIZ-BUIJSSE, M.M. SCHELLEKENS, S. RAMDIEN-MURLI, E. BLEZER, M. VAN MEURS, J. CEUPPENS,
M. DE BOER, B.A. 'T HART AND J.D. LAMAN. Prevention of experimental autoimmune encephalomyelitis in the common marmoset
(Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B-cell responses.
Journal of Immunology 167:2942-2949 (2001).
- B.A. 'T HART, H.P.M. BROK, L. MASSACESI, J. BAUER, L. BOON, R.E. BONTROP AND J.D. LAMAN A new primate model for
multiple sclerosis in the common marmoset. Immunology Today, 21(6): 290-7 (2000)
- BROK, H.P. ET AL. (2000) Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets:
the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. J Immunol 165 (2), 1093-1101.
- J.D. LAMAN, B.A. 'T HART, H.P.M. BROK, M. VAN MEURS, A. KASRAN, L. BOON, J. BAUER, M. DE BOER AND J. CEUPPENS.
Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12). European
Journal of Immunology 32: 2218-2228 (2002).
- A´T HART BA AND AMOR S. The use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the
central nervous system.Curr Opin Neurol. 2003 Jun;16(3):375-83. Review.
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