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LIBLAU Roland
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Tel.: +33-5-6274-4515
Fax: +33-5-6177-9401
e-mail:
rolandliblau@hotmail.com
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Address
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INSERM U563 : " Autoimmunity and Immunoregulation "
Hôpital PURPAN
Place Dr Baylac
31000 Toulouse- FRANCE
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Research themes
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Study of organ-specific autoimmune diseases in transgenic mice
Pathophysiology of EAE
Role of CD8 T cells in EAE and MS
Immunogenetics of multiple sclerosis
Antigen-specific immunotherapy
Regulation of autoimmunity
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Key words
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Multiple sclerosis, EAE, autoimmunity, antigen-specific immunotherapy, infection and autoimmunity
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Methods
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Cell cultures
Cellular immunology : T cell proliferation, cytokine production, FACs analysis
Molecular biology : generation of transgenic mice, RT-PCR
Animal models of autoimmune diseases
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Composition of the research group
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BEAUMEL Sabine
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Lab Technician
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INSERM U563
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CABARROCAS Julie
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Veterinarian, PhD student
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INSERM U563
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CASSAN Cécile
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PhD student
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INSERM U563
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Mars Lennart
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Post-doctoral fellow
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INSERM U563
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LIBLAU Roland
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MD, PhD
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Immunology department and INSERM
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ZAPULLA Jacques
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Post-doctoral fellow
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INSERM U563
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PIAGGIO Eliane
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Post-Doctoral fellow
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INSERM U563
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Recent publications
- CORNET A, SAVIDGE T, CABARROCAS J, DENG WL, COLOMBEL JF, LASSMANN H, DESREUMAUX P, LIBLAU R. Enterocolitis induced by autoimmune targeting of enteric glial cells :
a possible mechanism in Crohn's disease. Proc. Natl. Acad. Sci USA. 2001; 98: 13306-11.
- VAN WEYENBERGH J, WIETZERBIN J, ROUILLARD D, BARRAL-NETTO M, LIBLAU R Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic
cell death J Leukoc Biol. 2001; 70: 745-8.
- MARS L., V LALOUX, K GOUDE, L VAN KAER, H. LASSMANN, A HERBELIN, A LEHUEN, LIBLAU R Cutting edge : Regulatory function of va14-ja281 nkt cells in experimental autoimmune
encephalomyelitis J. Immunol. 2002; 168 : 6007-6011.
- LIBLAU R.S., WONG F.S., MARS L.T., SANTAMARIA P. Autoreactive CD8 T cells in organ-specific autoimmunity : emerging targets for
therapeutic intervention. Immunity. 2002; 17 : 1-6.
- PICARD-RIERA N., DECKER L., DELARASSE C., GOUDE K., LIBLAU R., PHAM-DINH D., BARON-VAN EVERCOOREN A. Experimental Autoimmune Encephalomyelitis Mobilizes
Neural Precursor Cells From The Subventricular Zone To Undergo Oligodendrogenesis In Adult Mice. Proc. Natl. Acad. Sci (USA). 2002; 99: 13211-13216.
- DUPLAN V, DUTARTRE P, MARS LT, LIBLAU RS, DRUET P, SAOUDI A. LF 15-0195 Inhibits the Development of Rat Central Nervous
System Autoimmunity by Inducing Long-Lasting Tolerance in Autoreactive CD4 T Cells. J. Immunol. 2003; 170: 2179-85.
- CABARROCAS J, BAUER J, PIAGGIO E, LIBLAU R, LASSMANN H. Effective and selective immune surveillance of the brain by MHC class I-restricted
cytotoxic T lymphocytes. Eur J Immunol. 2003; 33: 1174-82.
- DELARASSE, C., P. DAUBAS, L. MARS, C. VIZLER, B. DELLA GASPERA, L. DECKER, J. BAUER, T. LITZENBURGER, A. IGLESIAS, A. SCHUBART,
D. DIMITRI, A. DIERICH, M. LEMEUR, G. ROUSSEL, J.-L. NUSSBAUM, , A. DAUTIGNY*, R. LIBLAU*, AND D. PHAM-DINH*. Myelin/Oligodendrocyte
Glycoprotein (MOG)-deficient mice reveal lack of tolerance to MOG in wild-type mice. J. Clin. Invest. 2003; 112:544-53
- ALIZADEH M, BABRON MC, BIREBENT B, MATSUDA F, QUELVENNEC E, LIBLAU R, COURNU-REBEIX I,
MOMIGLIANO-RICHIARDI P, SEQUEIROS J, YAOUANQ J, GENIN E, VASILESCU A, BOUGERIE H, TROJANO M, MARTINS SILVA B,
MACIEL P, CLERGET-DARPOUX F, CLANET M, EDAN G, FONTAINE B, SEMANA G. Genetic interaction of CTLA-4 with HLA-DR15
in multiple sclerosis patients. Ann Neurol. 2003; 54(1):119-22.
- FISSON S, DARRASSE-JEZE G, LITVINOVA E, SEPTIER F, KLATZMANN D, LIBLAU R, SALOMON BL Continuous Activation of
Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State. J Exp Med.2003; Aug 25 [Epub ahead of print]
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