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LININGTON, Chris

Tel.: +44-1224-555796

Fax: +44-1224-555766

e-mail: c.linington@abdn.ac.uk

 

Address

Institute of Medical Sciences

Department of Medicine and Therapeutics

University of Aberdeen

Foresterhill, Aberdeen AB25 2ZD

Scotland, UK

Research themes

Role of antigen-specific T and B cell responses in the immunopathogenesis of inflammatory/demyelinating diseases of the nervous system, environmental modulation of the autoimmune repertoire, immunobiology of tissue injury and repair in the central nervous system, animal models of multiple sclerosis

Key words

Myelin structure and biochemistry, B cells, T cells, macrophages, inflammatory mediators, demyelination, remyelination, axonal injury, MS, EAE

Methods

Cellular immunology (Functional T and B cell assays: proliferation, chemokine, cytokine and cytotoxicity assays using ELISA and FACS based methodologies), generation of autoreactive antigen-specific T cell lines and clones, protein analyses, molecular biology (recombinant DNA techniques, PCR methologies, transgenics), immunocytochemistry, confocal and electron microscopy, animal models (EAE, EAN, EAU)

Composition of the research group

Emily Mathey

PhD

Dept. of Medicine and Therapeutics University of Aberdeen

Kieran Williams

PhD

Dept. of Medicine and Therapeutics University of Aberdeen

Recent publications

  1. KAWAKAMI N, LASSMANN S, LI Z, ODOARDI F, RITTER T, ZIEMSSEN T, KLINKERT WEF, ELLWART J, BRADL M, KRIVACIC K, LASSMANN H, RANSOHOFF RM, VOLK H, WEKERLE H, LININGTON C AND FLÜGEL A. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med. (2004) in press

  2. GUGGENMOS J. HAASE CG. OGG S. BREHM U. ANDERSSON M. OLSSON T. MATHER I. LININGTON C. Antibody crossreactivity between the milk protein butryophilin and myelin oligodendrocyte glycoprotein in multiple sclerosis.. J. Immunol. 172: 661-8 (2004).

  3. MEAD RJ, NEAL JW, GRIFFITHS MR, LININGTON C, BOTTO M, LASSMANN H, MORGAN BP.Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest. 84: 21-8 (2004).

  4. PAGANY M, JAGODIC M, SCHUBART A, PHAM-DINH D, BACHELIN C, BARON VAN EVERCOOREN A, LACHAPELLE F, OLSSON T, LININGTON C. Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates. Neurosci Lett. 350(3): 165-8 (2004)

  5. BOURQUIN C, SCHUBART A, TOBOLLIK S, MATHER I, OGG S, LIBLAU R, LININGTON C. Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. J. Immunol 171(1):455-61 (2003)

  6. BREITHAUPT C, SCHUBART A, ZANDER H, SKERRA A, HUBER R, LININGTON C, JACOB U. Structural Insights into the Antigenicity of Myelin Oligodendrocyte Glycoprotein. Proc. Nat. Acad. Sci. USA 100:9446-51 (2003)

  7. PAGANY M, JAGODIC M, BOURQUIN C, OLSSON T, LININGTON C. Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis. J Neuroimmunol 139: 1-8 (2003).

  8. BETTELLI E, PAGANY M, WEINER HL, LININGTON C, SOBEL RA, KUCHROO VK. Myelin Oligodendrocyte Glycoprotein-specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis. J Exp Med. 197: 1073-81 (2003).

  9. ABDUL-MAJID KB, STEFFERL A, BOURQUIN C, LASSMANN H, LININGTON C, OLSSON T, KLEINAU S, HARRIS RA Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scand J Immunol 55: 70-81 (2002).

  10. POPOVIC N, SCHUBART A, GOETZ B.D, ZHANG S.C, LININGTON C, DUNCAN D. Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann. Neurol 51: 215-223 (2002)

  11. HAASE CG, GUGGENMOS J, BREHM U, ANDERSSON M, OLSSON T, REINDL M, SCHNEIDEWIND JM, ZETTL UK, HEIDENREICH F, BERGER T, WEKERLE H, HOHLFELD R, LININGTON C. The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J. Neuroimmunol. 114: 220-225 (2001).

  12. IGLESIAS A, BAUER J, LITZENBURGER T, SCHUBART A, LININGTON C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia. 36: 220-234 (2001).

  13. GOLD R. AND LININGTON C. Devic's disease: bridging the gap between laboratory and clinic. Brain. 125: 1425-7 (2001).

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