|
WILLISON Hugh John
|
Tel.: +44 (0)141 201 1100/2464/2474
Fax: +44 (0)141 201 2993
e-mail:
h.j.willison@clinmed.gla.ac.uk
|
|
Address
|
Division of Clinical Neurosciences
University Department of Neurology
Institute of Neurological Sciences
Southern General Hospital NHS Trust
Glasgow - G51 4TF
Scotland
|
|
Research themes
|
The pathogenesis of autoimmune neuropathy mediated by anti-ganglioside antibodies: clinical and experimental studies.
|
|
Key words
|
Autoimmune neuropathy, autoantibodies, Guillain Barre syndrome, Miller Fisher syndrome, gangliosides
|
|
Methods
|
Immunoassays, antibody cloning and characterisation, animal modelling
|
|
Composition of the research group
|
|
Judith BOFFEY
|
Postdoctoral research scientist
|
|
|
Sue HALSTEAD
|
Postdoctoral research scientist
|
|
|
Jean VEITCH
|
Technician
|
|
|
Eric WAGNER
|
Technician
|
|
|
Pat THOMSON
|
Technician
|
|
|
Peter HUMPHREYS
|
Technician
|
|
|
John GOODFELLOW
|
PhD student
|
|
|
Kate TOWNSON
|
PhD student (joint, Prof N Isaacs)
|
|
|
Edina SILAJDZIC
|
PhD Student (joint, Dr SC Barnett)
|
|
|
Recent publications
- ANG CW, LAMAN JD, WILLISON HJ, WAGNER ER, ENDTZ HP,
DE KLERK MA, TIO-GILLEN AP, VAN DEN BRAAK N, JACOBS BC,
DOORN PA.Structure of Campylobacter jejuni lipopolysaccharides
determines antiganglioside specificity and clinical features
of Guillain-Barre and Miller Fisher patients. Infect Immun
2002; 70:1202-8.
- JACOBS BC, BULLENS RW, O'HANLON GM, ANG CW, WILLISON HJ, PLOMP JJ. Detection and prevalence of alpha-latrotoxin-like effects
of serum from patients with Guillain-Barre syndrome. Muscle Nerve. 2002; 25:549-58.
- BOWES T, WAGNER ER, BOFFEY J, NICHOLL D, COCHRANE L, BENBOUBETRA M, CONNER J, FURUKAWA K, FURUKAWA K, WILLISON HJ. Tolerance to self gangliosides is the major factor restricting the
antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain Barre syndrome. Infection and Immunity 2002, 70:5008-5018.
- BULLENS RWM, O'HANLON GM, WAGNER E, MOLENAAR PC, FURUKAWA K, FURUKAWA K, PLOMP JJ, WILLISON HJ. Complex gangliosides at the
neuromuscular junction are essential receptors for autoantibodies and botulinum neurotoxin but redundant for normal synaptic function.
J. Neuroscience 2002; 22:6876-6884.
- OOI MH, WONG SC, CLEAR D, PERERA D, KRISHNAN S, PRESTON T, TIO PH, WILLISON HJ, TEDMAN B, KNEEN R, CARDOSA MJ, SOLOMON T. Adenovirus type 21-associated
acute flaccid paralysis during an outbreak of hand-foot-and-mouth disease in Sarawak, Malaysia. Clin Infect Dis. 2003;36:550-9.
- JACOBS BC, O'HANLON GM, BULLENS RMW, VEITCH J, PLOMP JJ, WILLISON HJ. Immunoglobulins inhibit pathophysiological effects of anti-GQ1b positive
sera at motor nerve terminals through inhibition of antibody binding. Brain 2003; 126:2220-2234.
- O'HANLON GM, HUMPHREYS PD, GOLDMAN RS, HALSTEAD SK, BULLENS RWM, PLOMP JJ, USHKARYOV Y, WILLISON HJ. Calpain inhibitors protect against axonal
degeneration in a model of anti-ganglioside antibody mediated motor nerve terminal injury. Brain 2003; 126:2497-2509.
- PRITCHARD J, HUGHES RA, REES JH, WILLISON HJ, NICOLL JA. Apolipoprotein E genotypes and clinical outcome in Guillain-Barre
syndrome. J Neurol Neurosurg Psychiatry. 2003;74:971-973.
- O'HANLON GM, HIRST TR, WILLISON HJ. Ganglioside GM1 binding toxins and human neuropathy-associated IgM antibodies
differentially promote neuritogenesis in a PC12 assay. Neuroscience Research 2003; 47:383-390.
- WILLISON HJ, TOWNSON K, VEITCH J, BOFFEY J, ISAACS N, ANDERSEN S, ZHANG P, LING CC, BUNDLE DR. Synthetic disialylgalactose immunoadsorbents
deplete anti-GQ1b antibodies from autoimmune neuropathy sera.. Brain 2004.
- LEE G, JEONG Y, WIRGUIN I, HAYS AP, WILLISON HJ, LATOV N. Induction of human IgM and IgG anti-GM1 antibodies in transgenic
mice in response to lipopolysaccharides from Campylobacter jejuni. J. Neuroimmunol 2004; 46:63-75.
|
|
|
