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Selmaj Krzysztof
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Tel.: +4842-678-7746
Fax: +4842-678-2293
email:
kselmaj@afazja.am.lodz.pl
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Address |
Department of Neurology
Medical University of Lodz
ul. Kopcinskiego 22
90-153 Lodz, Poland |
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Research themes |
Role of cytokines, chemokines and T cells in central nervous system (CNS) demyelination. Mechanisms of apoptosis in CNS during autoimmune demyelination. Development of immune and gene-therapies for demyelinating diseases. |
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Key words |
Cytokines, chemokines, T cells, CNS demyelination, autoimmunity, apoptosis, gene polymorphism, heat shock proteins, oligodendrocytes, multiple sclerosis, experimental autoimmune encephalomyelitis |
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Methods |
Molecular biology (PCR, RPA, Southern and Northern blotting, recombinant DNA techniques), cellular immunology (T cell proliferation and cytotoxic assays, FACS analysis), cytokine and chemokine detection techniques (ELISA, RT-PCR, RPA, immunohisto- chemistry), protein analyses (Western blotting, HPLC), cell cultures (PBMC, oligodendrocytes, microglia), animal models (EAE, ChREAE) |
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Composition of the research group |
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Krzysztof Selmaj |
MD, PhD, Neurologist |
Medical University of Lodz |
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Andrzej Glabinski |
MD, PhD, Neurologist |
Medical University of Lodz |
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Anna Jurewicz |
MD, PhD, Neurologist |
Medical University of Lodz |
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Tomasz Berkowicz |
MD, PhD, Neurologist |
Medical University of Lodz |
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Marcin Mycko |
MD, PhD, Neurologist |
Medical University of Lodz |
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Agata Walczak |
MD, PhD, Neurologist |
Barlicki Hospital |
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Jolanta Nowicka |
MD, Neurologist |
Medical University of Lodz |
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Grazyna Galazka |
PhD, Biochemistry |
Medical University of Lodz |
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Bozena Szymanska |
PhD, Molecular Biology |
Medical University of Lodz |
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Ewa Tronczynska |
BS, Biologist |
Medical University of Lodz |
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Hanna Cwiklinska |
BS, Chemistry |
Medical University of Lodz |
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Recent publications
1. Glabinski A.R, Balasingam V, Tani M, Kunkel SL, Strieter RM, Yong VW, Ransohoff RM. (1996) Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol, 156, 4363-4368.
2. Glabinski AR, Tani M, Strieter RM, Tuohy VK, Ransohoff RM. (1997) Synchronous synthesis of a- and b-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol, 150, 617-630.
3. Mycko M., Kwinkowski M., Tronczynska E., Szymanska B., Selmaj K. (1998) Multiple Sclerosis: The Increased Frequency of the ICAM -1 Exon 6 Gene Point Mutation Genetic Type K469. Ann Neurol. 44, 70-75.
4. Jurewicz A., Biddison W., Antel J. (1998) MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes. J. Immunol. 160, 3056-3059.
5. Selmaj K., Walczak A., Mycko M., Berkowicz T.,Tadahiko K., Raine C. (1998) Suppression of experimental autoimmune encephalomyelitis with a TNF binding protein (TNFbp)correlates with down-regulation of VCAM-1/VLA-4. Eur. J. Immunol. 28, 2035-2044.
6. Mycko M., Kowalski W., Kwinkowski M., Buenafe A.C., Szymanska B., Tronczynska E., Plucienniczak A., Selmaj K. (1998) Multiple Sclerosis: The Frequency of allelic forms of tumor necrosis factor and lymphotoxin - alpha. J. Neuroimmunol. 84, 198-206.
7. Glabinski AR, Krakowski M, Han Y, Owens T, Ransohoff RM. (1999) Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J. Neurovirol. 5, 95-101.
8. Flugel.A., Willem M, Berkowicz T., Wekerle H. (1999) Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Med. 843-7.
9. Jurewicz A., Walczak, A., Selmaj K. (1999) Shedding of TNF receptors in multiple sclerosis patients. Neurology 53, 1409-1414.
10. Szymanska B., Rajan A., Gao Y., Tronczynska E., Brosnan C., Selmaj K. (1999) Evidence for gd T cells with a restricted Vd 6 junctional region in the normal mouse central nervous system. J. Neuroimmunol. 100, 260-265.
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